Successfully completing lab work can be challenging. Whether the lab is engaged in innovative, cutting-edge research or delivering highly accurate and precise diagnostic data, the nature of the work can drain the spirit and the energy from the staff. Lab managers need to recognize the needs and the benefits of staff well-being to provide sustainable technical outcomes for customers, patients, and stakeholders. Most lab managers are promoted from the bench and receive little, if any, training on the people aspects of the role. Professor Mandy O’Neill of George Mason University is an expert in organizational well-being. Here are her five priorities to drive well-being in the lab.